Studies & Materials

New photobiomodulation device for prevention and cure of radiotherapy‑induced oral mucositis and dermatitis: results of the prospective Safe PBM study
  • Safe PBM is a French, multicentric, prospective, non-comparative study which include patients with head and neck cancer or breast cancer treated in prophylactic or curative setting.
  • CareMin650 is feasible, safe, and well tolerated for preventive or curative treatment of OM and RD in cancer patients treated with RT.

Systematic review of photobio­modulation for the management of oral mucositis in cancer patients and clinical practice guidelines.
  • PBM is recommended for the prevention of OM & related pain in cancer patients treated with hematopoietic stem cell transplantation, H&N radiotherapy and H&N radiotherapy with chemotherapy.
Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial.
  • LLLT decreases severity of OM and oral pain
  • Lesser weight loss, less morphine analgesic use and less radiation break in LLLT group
A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis.
  • Consistent evidence that red & infrered LLLT can partly prevent development of cancer therapy-induced OM
  • LLLT reduces significantly pain, severity & duration of symptoms in patients with cancer therapy-induced OM
  • Limitation of laser therapy due to heterogeneous laser parameters